methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate

Base Information

• Chemical Name: methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate
• CAS No.: 1180491-74-0
• Molecular Formula: C₂₆H₂₄O₇
• Molecular Weight: 448.472
• Mol file: 1180491-74-0.mol

Synonyms:methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate

Chemical Property of methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate

There total 21 articles about methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C18H15BrO5 + 3,5-dimethoxyphenylboronic acid (192182-54-0) → methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate (1180491-74-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c6ob01657j

Reference yield: 70.0%

methyl 3-(3,5-dimethoxyphenyl)-6-methoxybenzofuran-4-carboxylate (1180491-75-1) + 4-methoxyphenylboronic acid (5720-07-0) → methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate (1180491-74-0) + dimethyl 3,3'-bis(3,5-dimethoxyphenyl)-6,6'-dimethoxy-2,2'-bibenzofuran-4,4'-dicarboxylate (1180491-78-4)

Guidance literature:

With potassium acetate; palladium diacetate; In 2,4-dichlorophenoxyacetic acid dimethylamine; at 80 ℃;

DOI:10.1039/b901911a

Reference yield: 68.0%

C23H18O7 + dimethyl sulfate (77-78-1) → methyl 3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-carboxylate (1180491-74-0)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Reflux;

DOI:10.1021/acs.joc.7b03089

upstream raw materials:

1-bromo-4-methoxy-benzene

methyl 3-(3,5-dimethoxyphenyl)-6-methoxybenzofuran-4-carboxylate

para-iodoanisole

4-methoxyphenylboronic acid

Downstream raw materials:

3-(3,5-dimethoxyphenyl)-(6-methoxy-2-(4-methoxyphenyl)-benzofuran-4-yl) methanol

4,7,9-trihydroxy-1-(4-hydroxyphenyl)-6H-anthra[1,9-bc]furan-6-one

4,7,9-trimethoxy-1-(4-methoxyphenyl)-6H-anthra[1,9-bc]furan-6-one

3-(3,5-dimethoxyphenyl)-6-methoxy-2-(4-methoxyphenyl)benzofuran-4-carboxylic acid