(R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Base Information

• Chemical Name: (R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid
• CAS No.: 954388-33-1
• Molecular Formula: C18H24 N2 O6
• Molecular Weight: 364.39
• Hs Code.: 2933599590
• European Community (EC) Number: 675-825-8
• DSSTox Substance ID: DTXSID20424921
• Mol file: 954388-33-1.mol

Synonyms:954388-33-1;(R)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid;(R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(2R)-1-[(benzyloxy)carbonyl]-4-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid;(r)-1-(benzyloxycarbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;(R)-Piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester;(2R)-4-[(2-methylpropan-2-yl)oxycarbonyl]-1-phenylmethoxycarbonylpiperazine-2-carboxylic acid;(r)-4-boc-1-cbz-piperazine-2-carboxylic acid;SCHEMBL2442588;(R)-4-tert-Butoxycarbonyl-1-(benzyloxycarbonyl)piperazine-2-carboxylic acid;DTXSID20424921;MFCD04115324;AKOS015911686;DS-5050;A13031;EN300-7418971;(r)-n-4-boc-n-1-cbz-2-piperazinecarboxylic acid;(r)-1,2,4-piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester;(R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid;1,2,4-Piperazinetricarboxylicacid, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R)-

Chemical Property of (R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.36E-11mmHg at 25°C
• Boiling Point: 518.9°C at 760 mmHg
• Flash Point: 267.6°C
• PSA: 96.38000
• Density: 1.272
• LogP: 2.20490
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 364.16343649
• Heavy Atom Count: 26
• Complexity: 524

Purity/Quality:

97% ^*data from raw suppliers

(R)-Piperazine-1,2,4-tricarboxylicacid1-benzylester4-tert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCN(C(C1)C(=O)O)C(=O)OCC2=CC=CC=C2
• Isomeric SMILES: CC(C)(C)OC(=O)N1CCN([C@H](C1)C(=O)O)C(=O)OCC2=CC=CC=C2

Technology Process of (R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

There total 1 articles about (R)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester (954388-33-1)

Guidance literature:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (R)-piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester (954388-33-1) → 1‐benzyl 4‐tert‐butyl (2S)‐2‐(2‐methoxy‐2‐oxoethyl)piperazine‐1,4‐dicarboxylate (314741-49-6)

Guidance literature:

(R)-piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at 0 ℃; for 3h;

diazomethane; In ethyl acetate; at 20 ℃; for 18h;

With silver benzoate; triethylamine; In methanol; at 0 - 20 ℃; for 18h;

Reference yield:

(R)-piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester (954388-33-1) + 2,2,2-trifluroethylamine hydrochloride (373-88-6) → 1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate (1346172-65-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Downstream raw materials:

1‐benzyl 4‐tert‐butyl (2S)‐2‐(2‐methoxy‐2‐oxoethyl)piperazine‐1,4‐dicarboxylate

1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

tert-butyl (3R)-4-(6-{5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrazin-2-yl)-3-[(2,2,2-trifluoroethyl)carbamoyl]piperazine-1-carboxylate

(2R)-1-(6-{5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrazin-2-yl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide hydrochloride