1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

Base Information

Chemical Name:1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate
CAS No.:1346172-65-3
Molecular Formula:C₂₀H₂₆F₃N₃O₅
Molecular Weight:445.439
Hs Code.:

Synonyms:1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

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Chemical Property of 1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

Chemical Property:

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Technology Process of 1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

There total 1 articles about 1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954388-33-1
(R)-piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 373-88-6
2,2,2-trifluroethylamine hydrochloride

: 1346172-65-3
1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1346172-65-3
1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

: 1346172-68-6
tert-butyl (3R)-4-(6-{5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrazin-2-yl)-3-[(2,2,2-trifluoroethyl)carbamoyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 19 h / 100 - 170 °C / Microwave irradiation

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Microweve irradiation

With hydrogen; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1346172-65-3
1-benzyl 4-tert-butyl (2R)-2-[(2.2,2-trifluoroethyl)carbamoyl]piperazine-1,4-dicarboxylate

: 1346172-70-0
(2R)-1-(6-{5-chloro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrazin-2-yl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 19 h / 100 - 170 °C / Microwave irradiation

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Microweve irradiation

4: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;