N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

Base Information

Chemical Name:N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide
CAS No.:1338814-69-9
Molecular Formula:C₃₃H₃₄N₆O₃S
Molecular Weight:594.737
Hs Code.:

Synonyms:N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

There total 7 articles about N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 38870-89-2
Methoxyacetyl chloride

: 1338815-63-6
1-(4-(2-aminopyridin-4-ylthio)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

: 1338814-69-9
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.583333h;

Reference yield:

: 341-92-4
1-fluoro-4-nitronaphthalene

: 1338814-69-9
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogen sulfide / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C / Inert atmosphere

1.2: 49.08 h / 20 °C / Inert atmosphere

2.1: hydrogen; acetic acid / 10% Pt/activated carbon / ethyl acetate; methanol / 50 °C

3.1: 24 h / 120 °C

4.1: hydrogenchloride; water / methanol / 3 h / 50 - 70 °C

5.1: dichloromethane / 1.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / 20 °C

With hydrogenchloride; sodium hydrogen sulfide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; 10% Pt/activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate;

Reference yield:

: 34941-91-8
2-chloro-4-fluoropyridine

: 1338814-69-9
N-(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-ylthio)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogen sulfide / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C / Inert atmosphere

1.2: 49.08 h / 20 °C / Inert atmosphere

2.1: hydrogen; acetic acid / 10% Pt/activated carbon / ethyl acetate; methanol / 50 °C

3.1: 24 h / 120 °C

4.1: hydrogenchloride; water / methanol / 3 h / 50 - 70 °C

5.1: dichloromethane / 1.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / 20 °C

With hydrogenchloride; sodium hydrogen sulfide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; 10% Pt/activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate;