2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile

Base Information

• Chemical Name: 2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile
• CAS No.: 75288-86-7
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• Mol file: 75288-86-7.mol

Synonyms:2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile

Chemical Property of 2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile

There total 1 articles about 2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide (52590-27-9) + benzaldehyde (100-52-7) → 2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile (75288-86-7)

Guidance literature:

With sodium amalgam; sodium ethanolate; Yield given. Multistep reaction; 1.) aq. EtOH, 35 deg C, 4 h 2.) aq. EtOH, 50 deg C, 4 h;

DOI:10.1016/0040-4020(80)88003-3

Reference yield: 92.0%

2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile (75288-86-7) → 2-<2-β-(N-methylamino)ethyl-4,5-dimethoxyphenyl>-3-phenyl-propionic acid (75288-88-9)

Guidance literature:

With 10 percent NaOH; In sodium hydroxide; ethanol; for 20h; Heating;

DOI:10.1016/0040-4020(80)88003-3

Reference yield:

2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionitrile (75288-86-7) → 1,2,4,5-tetrahydro-7,8-dimethoxy-3-methyl-1-benzyl-3H-3-benzazaepin-2-one (75288-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 10 percent NaOH / aq. ethanol; aq. NaOH / 20 h / Heating

2: 85 percent / xylene / 16 h / Heating

With sodium hydroxide; In sodium hydroxide; ethanol; xylene;

DOI:10.1016/0040-4020(80)88003-3

upstream raw materials:

N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide

benzaldehyde

Downstream raw materials:

2-<2-β-(N-methylamino)ethyl-4,5-dimethoxyphenyl>-3-phenyl-propionic acid

2-<2-β-(N-methyl-N-acetylamino)ethyl-4,5-dimethoxyphenyl>-3-phenylpropionic acid

1,2,4,5-tetrahydro-7,8-dimethoxy-3-methyl-1-benzyl-3H-3-benzazaepin-2-one

N-{2-[4,5-Dimethoxy-2-(1-oxo-indan-2-yl)-phenyl]-ethyl}-N-methyl-acetamide