Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

Base Information

Chemical Name:Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH
CAS No.:1021397-62-5
Molecular Formula:C₆₀H₆₂ClN₇O₁₂
Molecular Weight:1108.64
Hs Code.:

Synonyms:Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

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Chemical Property of Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

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Technology Process of Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

There total 7 articles about Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947189-88-0
Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

: 1021397-62-5
Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 1.5h; under 760.051 Torr;
DOI:10.1021/ja068573k

Reference yield:

: 947189-86-8
Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine)-OBn

: 1021397-62-5
Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / tetrahydrofuran / 2 h / 25 °C / 760.05 Torr

2: 81 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; NaHCO₃ / dimethylformamide / 72 h / 0 °C

3: Bu₄NF / dimethylformamide; propan-2-ol / 0.17 h / 25 °C

4: 81 mg / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 72 h / 0 °C

5: H₂ / Pd/C / ethanol / 1.5 h / 25 °C / 760.05 Torr

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/ja068573k

Reference yield:

: 947190-30-9
Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine)-OH

: 1021397-62-5
Fmoc-L-Asn(Trt)-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OH

Guidance literature:: Multi-step reaction with 4 steps

1: 81 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; NaHCO₃ / dimethylformamide / 72 h / 0 °C

2: Bu₄NF / dimethylformamide; propan-2-ol / 0.17 h / 25 °C

3: 81 mg / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 72 h / 0 °C

4: H₂ / Pd/C / ethanol / 1.5 h / 25 °C / 760.05 Torr

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/ja068573k