Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

Base Information

Chemical Name:Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn
CAS No.:947189-87-9
Molecular Formula:C₄₄H₄₈ClN₅O₁₀
Molecular Weight:842.346
Hs Code.:

Synonyms:Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

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Chemical Property of Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

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Technology Process of Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

There total 5 articles about Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947189-86-8
Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine)-OBn

: 947189-87-9
Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 2 h / 25 °C / 760.05 Torr

2: 81 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; NaHCO₃ / dimethylformamide / 72 h / 0 °C

With hydrogen; sodium hydrogencarbonate; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja068573k

Reference yield:

: 436849-00-2
N-tert-butoxycarbonyl-(S)-3-chloro-4-hydroxyphenylglycine benzyl ester

: 947189-87-9
Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / ethyl acetate / 1 h / 25 °C

2: 90 percent / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 72 h / 0 °C

3: H₂ / Pd/C / tetrahydrofuran / 2 h / 25 °C / 760.05 Torr

4: 81 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; NaHCO₃ / dimethylformamide / 72 h / 0 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja068573k

Reference yield:

: L-Chp-OBn hydrochloride

: 947189-87-9
Fmoc-L-(2,3-diaminopropionic acid)(Boc-L-Ala-D-Ala-L-(3-chloro-4-hydroxyphenylglycine))-OBn

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 72 h / 0 °C

2: H₂ / Pd/C / tetrahydrofuran / 2 h / 25 °C / 760.05 Torr

3: 81 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; NaHCO₃ / dimethylformamide / 72 h / 0 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja068573k