C₁₉H₁₅ClS

Base Information

• Chemical Name: C₁₉H₁₅ClS
• CAS No.: 1256348-07-8
• Molecular Formula: C₁₉H₁₅ClS
• Molecular Weight: 310.847
• Mol file: 1256348-07-8.mol

Synonyms:C₁₉H₁₅ClS

Chemical Property of C₁₉H₁₅ClS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₅ClS

There total 4 articles about C₁₉H₁₅ClS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-(4-chlorophenyl)hepta-1,2-dien-6-yn-4-ol (1256347-99-5) + thiophenol (108-98-5) → C19H15ClS (1256348-07-8)

Guidance literature:

With indium (III) iodide; In 1,2-dichloro-ethane; at 80 ℃; for 1h; Inert atmosphere;

DOI:10.1002/asia.201000267

Reference yield:

1-(4-chlorophenyl)but-3-yn-1-ol (42249-99-0) → C19H15ClS (1256348-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: periodic acid; pyridinium chlorochromate / acetonitrile / 0 - 20 °C

2.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: indium (III) iodide / 1,2-dichloro-ethane / 1 h / 80 °C / Inert atmosphere

With indium (III) iodide; magnesium; periodic acid; pyridinium chlorochromate; mercury dichloride; In diethyl ether; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1002/asia.201000267

Reference yield:

4-chlorobenzaldehyde (104-88-1) → C19H15ClS (1256348-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere

1.2: -23 °C / Inert atmosphere

2.1: periodic acid; pyridinium chlorochromate / acetonitrile / 0 - 20 °C

3.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

4.1: indium (III) iodide / 1,2-dichloro-ethane / 1 h / 80 °C / Inert atmosphere

With indium (III) iodide; magnesium; periodic acid; pyridinium chlorochromate; mercury dichloride; In diethyl ether; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1002/asia.201000267

upstream raw materials:

4-(4-chlorophenyl)hepta-1,2-dien-6-yn-4-ol

thiophenol

1-(4-chlorophenyl)but-3-yn-1-ol

4-chlorobenzaldehyde

Refernces