(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Base Information

Chemical Name:(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid
CAS No.:452100-87-7
Molecular Formula:C₂₄H₂₆N₂O₃S
Molecular Weight:422.548
Hs Code.:

Synonyms:(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Suppliers and Price of (3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

There total 16 articles about (3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 28092-52-6
(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione

: 452100-87-7
(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Guidance literature:: (4-carboxybutyl)triphenylphosphonium bromide; With potassium tert-butylate; In toluene; at 25 ℃; for 0.75h;

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione; In toluene; at 135 ℃; for 7h;
DOI:10.1248/cpb.53.743

Reference yield: 72.0%

: 452100-86-6
(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid methyl ester

: 452100-87-7
(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Guidance literature:: With sodium hydroxide; water; In methanol; at 25 ℃; for 17h;
DOI:10.1021/jo025794+

Reference yield:

: 100-52-7
benzaldehyde

: 452100-87-7
(3aS,4Z,6aR)-5-{hexahydro-1,3-dibenzyl-2-oxo-4H-thieno[3,4-d]imidazol-4-ylidene}pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: citric acid; NaHCO₃; NaBH₃CN / H₂O; tetrahydrofuran / 2.5 h / 5 °C / pH 4

2: 1.4 g / HCl / H₂O; tetrahydrofuran / 21 h / 25 °C

3: 77 percent / NaHCO₃; triethyl phosphite; Pd(OAc)2 / tetrabutylammonium chloride / dimethylformamide; H₂O / 2 h / 100 °C

4: 92 percent / NaH / dimethylformamide / 21 h / -40 - 25 °C

5: 72 percent / H₂O; NaOH / methanol / 17 h / 25 °C

With hydrogenchloride; palladium diacetate; sodium hydroxide; water; sodium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; citric acid; triethyl phosphite; tetrabutyl-ammonium chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo025794+