2-Hydroxy-3-bromo-4-methylpyridine

Base Information

• Chemical Name: 2-Hydroxy-3-bromo-4-methylpyridine
• CAS No.: 18368-59-7
• Molecular Formula: C6H6 Br N O
• Molecular Weight: 188.024
• Hs Code.: 2933399090
• Mol file: 18368-59-7.mol

Synonyms:2(1H)-Pyridone,3-bromo-4-methyl- (8CI); 3-Bromo-4-methyl-2-(1H)-pyridinone

Chemical Property of 2-Hydroxy-3-bromo-4-methylpyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 323.221oC at 760 mmHg
• PKA: 10.56±0.10(Predicted)
• Flash Point: 149.279oC
• PSA: 32.86000
• Density: 1.622g/cm3
• LogP: 1.44580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-4-methyl-2-(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxy-3-bromo-4-methylpyridine

There total 6 articles about 2-Hydroxy-3-bromo-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3,5-dibromo-2-hydroxy-4-methylpyridine (89581-53-3) → 3-bromo-2-hydroxy-4-methylpyridine (18368-59-7)

Guidance literature:

3,5-dibromo-2-hydroxy-4-methylpyridine; With n-butyllithium; at -90 ℃;

With water; at -90 ℃;

DOI:10.1055/s-2003-41013

Reference yield:

2-hydroksy-4-methyl-pyridine (13466-41-6,91914-05-5) → 3-bromo-2-hydroxy-4-methylpyridine (18368-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 87 percent / NBS / acetonitrile / 1 h / Heating

2.1: n-BuLi / -90 °C

2.2: 50 percent / H₂O / -90 °C

With N-Bromosuccinimide; n-butyllithium; In acetonitrile;

DOI:10.1055/s-2003-41013

Reference yield:

3-bromo-2-chloro-4-methylpyridine (55404-31-4) → 3-bromo-4-methyl-1H-pyridin-2-one (18368-59-7)

Guidance literature:

With formic acid; In water; at 120 ℃; for 72h;

upstream raw materials:

3-bromo-2-chloro-4-methylpyridine

2-hydroksy-4-methyl-pyridine

3,5-dibromo-2-hydroxy-4-methylpyridine

2-Amino-4-methylpyridine

Downstream raw materials:

3-iodo-4-methyl-1-(3-(trifluoromethoxy)phenyl)pyridin-2(1H)-one

2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Refernces

• 1、 -. "OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)". Page/Page column 78; 79. . Retrieved 2013/03/26.
• 2、 -. "ALKYNE-SUBSTITUTED PYRIDONE COMPOUNDS AND METHODS OF USE". Page/Page column 32. . Retrieved 2008/06/13.