55404-31-4

Basic information

• Product Name: 3-BROMO-2-CHLORO-4-PICOLINE
• Synonyms: 3-BROMO-2-CHLORO-4-PICOLINE;2-CHLORO-3-BROMO-4-PICOLINE;3-BROMO-2-CHLORO-4-METHYLPYRIDINE;3-BROMO-2CHLORL-4-PICOLINE;2-Chloro-3-bromo-4-methylpyridine;3-Bromo-2-chloro-4-methyl...;3-Bromo-2-chloro-4-methylprinine;3-Bromo-2-chloro-4-methylpyridine 97%
• CAS NO: 55404-31-4
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.47
• Product Categories: Heterocycle-Pyridine series
• Mol File: 55404-31-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 250.3 °C at 760 mmHg
• Flash Point: 105.2 °C
• Appearance: /
• Density: 1.624 g/cm³
• Vapor Pressure: 0.0346mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.17±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-2-CHLORO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-CHLORO-4-PICOLINE(55404-31-4)
• EPA Substance Registry System: 3-BROMO-2-CHLORO-4-PICOLINE(55404-31-4)

Safety Data

• Hazardous Substances Data: 55404-31-4(Hazardous Substances Data)

Usage

Description

3-Bromo-2-chloro-4-picoline, a member of the picoline family, is a heterocyclic organic compound with the chemical formula C6H4BrClNO. It features a pyridine ring with bromine and chlorine substituents, making it a versatile intermediate in the synthesis of various chemical products.

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-chloro-4-picoline is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of complex organic molecules with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-2-chloro-4-picoline serves as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
3-Bromo-2-chloro-4-picoline is utilized as a building block in organic synthesis, particularly for the production of complex organic molecules, due to its reactive bromine and chlorine substituents which allow for further chemical reactions to create diverse chemical entities.

InChI:InChI=1/C6H5BrClN/c1-4-2-3-9-6(8)5(4)7/h2-3H,1H3

Upstream product

• 3430-22-6 3-Bromo-4-methylpyridin 
• 17117-15-6 3-bromo-4-methyl-1-oxidopyridin-1-ium 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 

Downstream Products

• 851607-30-2 3-bromo-5-chloro-2-methoxy-4-methylpyridine 
• 1429510-98-4 5-(2,4-dimethoxybenzyl)-7-(2-methoxy-4-methylpyridin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]quinolin-4(5H)-one 

Relevant articles and documents

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.