(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

Base Information

Chemical Name:(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)
CAS No.:1017605-64-9
Molecular Formula:C₃₉H₆₀N₄O₂
Molecular Weight:616.931
Hs Code.:

Synonyms:(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

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Chemical Property of (2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

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Technology Process of (2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

There total 3 articles about (2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1017605-63-8
(S)-N-(2,6-diisopropylphenyl)-piperidine-2-carboxamide

: 109-64-8
1,3-dibromo-propane

: 1017605-64-9
(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;
DOI:10.1002/anie.200704759

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1017605-64-9
(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.5 h / 0 °C

1.2: 24 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: potassium carbonate / acetonitrile / 24 h / Reflux

With potassium carbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.8b01744

Reference yield:

: 1017605-62-7
C₂₃H₃₆N₂O₃

: 1017605-64-9
(2S,2'S)-1,1'-(propane-1,3-diyl)bis(N-(2,6-diisopropylphenyl)piperidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: potassium carbonate / acetonitrile / 24 h / Reflux

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.8b01744