N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine

Base Information

• Chemical Name: N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine
• CAS No.: 121597-43-1
• Molecular Formula: C₂₉H₃₁FN₆O
• Molecular Weight: 498.603

Synonyms:N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine

Chemical Property of N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine

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Technology Process of N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine

There total 3 articles about N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-fluorophenyl)-3-(2-pyridyl)-1-propanamine (106670-55-7) → N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine (121597-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / diethyl ether / 1 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 1 h / Heating

3: 2) pyridine / 1) CH₂Cl₂, RT, 30 min, 2) reflux

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00128a045

Reference yield:

[3-(4-Fluoro-phenyl)-3-pyridin-2-yl-propyl]-carbamic acid ethyl ester → N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine (121597-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 2) pyridine / 1) CH₂Cl₂, RT, 30 min, 2) reflux

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00128a045

Reference yield:

3-[imidazol-4(5)-yl]propylamine (40546-33-6) + N-diphenoxymethylene benzamide (81282-38-4) + 3-(4-fluorophenyl)-3-pyridin-2-yl-N-methyl-1-propanamine (121597-92-0) → N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine (121597-43-1)

Guidance literature:

With pyridine; Yield given. Multistep reaction; 1) CH₂Cl₂, RT, 30 min, 2) reflux;

DOI:10.1021/jm00128a045

upstream raw materials:

3-[imidazol-4⁽⁵⁾-yl]propylamine

N-diphenoxymethylene benzamide

3-(4-fluorophenyl)-3-pyridin-2-yl-N-methyl-1-propanamine

3-(4-fluorophenyl)-3-(2-pyridyl)-1-propanamine

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