(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

Base Information

Chemical Name:(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt
CAS No.:960157-91-9
Molecular Formula:C₂₀H₁₉N₅O₃S₃*H₃N
Molecular Weight:490.631
Hs Code.:

Synonyms:(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

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Chemical Property of (S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

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Technology Process of (S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

There total 8 articles about (S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: C₂₀H₁₉N₅S₂

: 960157-91-9
(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

Guidance literature:: C₂₀H₁₉N₅S₂; With sulfur trioxide pyridine complex; In water; at 20 ℃; for 0.0833333h;

With ammonium hydroxide; In water;

Reference yield: 11.0%

: 960157-89-5
(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

: 960157-91-9
(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

Guidance literature:: (S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine; With palladium 10% on activated carbon; hydrogen; In methanol;

With pyridine; sulfur trioxide pyridine complex; at 20 ℃; for 0.0833333h;

With ammonium hydroxide;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 960157-91-9
(S)-4-[2-(5-methyl-1,3,4-thiadiazol-2-ylamino)-2-(2-phenylthiazol-4-yl)ethyl]phenylsulfamic acid ammonium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 24 h / Reflux

4.1: calcium carbonate / tetrachloromethane; water / 18 h / 20 °C

5.1: ethanol / 2 h / Reflux

5.2: 20 h / 20 - 50 °C

5.3: pH ~ 8

6.1: hydrogen / palladium 10% on activated carbon / methanol

7.1: pyridine; sulfur trioxide pyridine complex / 0.08 h / 20 °C

With pyridine; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; triethylamine; calcium carbonate; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; acetonitrile;