(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

Base Information

Chemical Name:(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine
CAS No.:960157-89-5
Molecular Formula:C₂₀H₁₇N₅O₂S₂
Molecular Weight:423.519
Hs Code.:

Synonyms:(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

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Chemical Property of (S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

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Technology Process of (S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

There total 9 articles about (S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 960157-87-3
(S)-4-(1-isothiocyanato-2-(4-nitrophenyl)ethyl)-2-phenylthiazole

: 1068-57-1
acetic acid hydrazide

: 960157-89-5
(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

Guidance literature:: (S)-4-(1-isothiocyanato-2-(4-nitrophenyl)ethyl)-2-phenylthiazole; acetic acid hydrazide; In ethanol; for 2h; Heating / reflux;

With trichlorophosphate; at 20 - 50 ℃; for 20h;

With sodium hydroxide; In water; ethyl acetate; pH=~ 8;

Reference yield: 93.0%

: 960157-87-3
(S)-4-(1-isothiocyanato-2-(4-nitrophenyl)ethyl)-2-phenylthiazole

: 6292-65-5
oxalic acid monohydrazide

: 960157-89-5
(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

Guidance literature:: (S)-4-(1-isothiocyanato-2-(4-nitrophenyl)ethyl)-2-phenylthiazole; oxalic acid monohydrazide; In ethanol; for 2h; Reflux;

With trichlorophosphate; In ethanol; at 20 - 50 ℃; for 20h;

Reference yield:

: 33305-77-0
Boc-Phe(p-NO₂)-OH

: 960157-89-5
(S)-5-methyl-N-[2-(4-nitrophenyl)-1-(2-phenylthiazol-4-yl)ethyl]-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogen bromide / water; tetrahydrofuran / 1.5 h / 0 °C

3.1: acetonitrile / 24 h / Reflux

4.1: calcium carbonate / tetrachloromethane; water / 18 h / 20 °C

5.1: ethanol / 2 h / Reflux

5.2: 20 h / 20 - 50 °C

5.3: pH ~ 8

With hydrogen bromide; triethylamine; calcium carbonate; isobutyl chloroformate; In tetrahydrofuran; tetrachloromethane; ethanol; water; acetonitrile;