(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Base Information

Chemical Name:(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol
CAS No.:461641-20-3
Molecular Formula:C₂₄H₂₉NO₂
Molecular Weight:363.5
Hs Code.:

Synonyms:(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Suppliers and Price of (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

There total 14 articles about (1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 461641-15-6
5-isopropyl-4-phenyl-1,9,9a,10a-tetrahydro-4H,4bH-10-oxa-4a-aza-indeno[1,2-a]indene-2-carboxylic acid ethyl ester

: 461641-20-3
(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1021/ol061405c

Reference yield:

: 65651-63-0,38836-21-4
4-hydroxy-5-methyl-hexan-2-one

: 461641-20-3
(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Guidance literature:: Multi-step reaction with 12 steps

1.1: 71 percent / p-TsOH*H₂O; Na₂SO₄ / benzene / 5 h / 90 °C

2.1: 79 percent / LiN(TMS)2 / tetrahydrofuran; toluene / 1.17 h / -78 - 20 °C

3.1: 2,5-di-tert-butylhydroquinone / benzene / 56 h / 200 °C

4.1: p-TsOH*H₂O / acetone / 0.5 h / 20 °C

5.1: 75 percent / p-cymene / Pd/C / 45 h / 200 °C

6.1: 97 percent / NaH / tetrahydrofuran / 2.5 h / 20 °C

7.1: 87 percent / NaBH₄; NiCl₂*6H₂O / methanol / 3 h / 0 - 20 °C

8.1: 100 percent / pTsOH*H₂O / benzene / 0.67 h / 20 - 100 °C

9.1: 86 percent / mCPBA; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; N-methylmorpholine N-oxide / CH₂Cl₂ / 1 h / -78 °C

10.1: H₂SO₄; acetonitrile / hexane / 1 h / 20 °C

10.2: 39 percent / H₂O / 2 h / 100 °C

11.1: CHCl₃ / 3 h / 24 °C

12.1: 1.12 g / LiAlH₄ / diethyl ether; tetrahydrofuran / 0.08 h / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; 4-methylisopropylbenzene; Mn(III) complex of (S,S)-1,2-cyclohexanediamine derivative; sulfuric acid; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; sodium sulfate; 3-chloro-benzenecarboperoxoic acid; acetonitrile; nickel dichloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; acetone; toluene; benzene; 3.1: Diels-Alder reaction / 9.1: Jacobsen reaction / 10.1: Ritter reaction;
DOI:10.1021/jo049381f

Reference yield:

: 461640-97-1
(1S,2R)-(-)-cis-1-amino-7-isopropylindan-2-ol

: 461641-20-3
(1S,2R)-(-)-cis-1-[(2R)-4-hydroxymethyl-2-phenyl-1,2,5,6-tetrahydropyridin-1-yl]-7-isopropylindan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 4 Angstroem molecular sieves; LiCl; P(2-furyl)3 / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethylformamide / 1 h / 80 °C

2: 87 percent / DIBAL-H / toluene / 1 h / -78 °C

With trifuran-2-yl-phosphane; 4 A molecular sieve; diisobutylaluminium hydride; lithium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol061405c