5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

Base Information

Chemical Name:5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine
CAS No.:1198211-32-3
Molecular Formula:C₁₈H₂₅FN₂OSi
Molecular Weight:332.493
Hs Code.:

Synonyms:5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

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Chemical Property of 5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

Chemical Property:

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Technology Process of 5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

There total 4 articles about 5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1198273-64-1
(2-bromo-6-fluorobenzyloxy)-tert-butyldimethylsilane

: 1198211-32-3
5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 360575-28-6
2-bromo-6-fluorobenzaldehyde

: 1198211-32-3
5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate / 1 h / Cooling with ice

2: 1H-imidazole / tetrahydrofuran / 16 h

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With 1H-imidazole; methanol; sodium tetrahydroborate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 261723-33-5
(2-bromo-6-fluorophenyl)methanol

: 1198211-32-3
5-[2-(tert-butyldimethylsilanyloxymethyl)-3-fluorophenyl]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / tetrahydrofuran / 16 h

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With 1H-imidazole; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;