N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

Base Information

Chemical Name:N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide
CAS No.:1366129-97-6
Molecular Formula:C₃₁H₃₁N₅O₄S₂
Molecular Weight:601.75
Hs Code.:

Synonyms:N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

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Chemical Property of N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

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Technology Process of N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

There total 12 articles about N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1366129-97-6
N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

Guidance literature:: Multi-step reaction with 5 steps

1: ISOPROPYLAMIDE / 0 - 20 °C

2: iron; ammonium chloride / ethanol; water / 1 h / Reflux

3: pyridine; dmap / 1 h / Inert atmosphere

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

5: potassium phosphate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; butan-1-ol / 20 h / 100 °C

With pyridine; dmap; potassium phosphate; potassium acetate; iron; ammonium chloride; XPhos; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; ethanol; ISOPROPYLAMIDE; water; butan-1-ol; 4: Suzuki Coupling / 5: Suzuki Coupling;

Reference yield:

: 1366129-69-2
6-chloro-3-[4-(ethylsulfonyl)phenyl]-2-quinolinamine

: 1366131-88-5
C₂₀H₂₈BN₃O₄S

: 1366129-97-6
N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

Guidance literature:: With potassium phosphate; XPhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; butan-1-ol; at 100 ℃; for 20h;

Reference yield:

: 612-57-7
6-chloroquinoline

: 1366129-97-6
N-{5-{2-amino-3-[4-(ethylsulfonyl)phenyl]-6-quinolinyl}-2-[(1-methylethyl)amino]-3-pyridinyl}benzenesulfonyamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / acetic acid / 3.5 h / 70 - 115 °C

2: trifluoromethylsulfonic anhydride; urea hydrogen peroxide adduct / dichloromethane

3: trichlorophosphate / 1 h / Reflux

4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 40 h / 130 °C / Sealed tube

5: trifluoroacetic acid / 3 h / 65 °C

6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 2 h / 80 °C

7: potassium phosphate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; butan-1-ol / 20 h / 100 °C

With potassium phosphate; N-Bromosuccinimide; trifluoromethylsulfonic anhydride; potassium acetate; urea hydrogen peroxide adduct; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; XPhos; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; acetic acid; butan-1-ol; 6: Suzuki Coupling / 7: Suzuki Coupling;