(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

Base Information

Chemical Name:(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester
CAS No.:145967-60-8
Molecular Formula:C₁₅H₁₈N₂O₅
Molecular Weight:306.318
Hs Code.:

Synonyms:(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

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Chemical Property of (2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

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Technology Process of (2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

There total 6 articles about (2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 145967-58-4
(S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester

: 145967-60-8
(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; for 72h; Ambient temperature;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 145967-60-8
(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

2: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

With 2,6-dimethylpyridine; (CF₃SO₂)2; triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)60843-2

Reference yield:

: 1738-72-3
L-serine benzyl ester

: 145967-60-8
(2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dioxane; H₂O

2: HN₃, diisopropyl azodicarboxylate, Ph₃P / 18 h / -78 deg C to r.t.

3: TFA / CH₂Cl₂ / 0.5 h / 0 deg C to r.t.

4: 1) (CF₃SO₂)2, 2) 2,6-lutidine / 1) CH₂Cl₂, -78 deg C, 5 min 2) CH₂Cl₂, -78 deg C to r.t., 18h

5: 85 percent / Ph₃P / tetrahydrofuran; H₂O / 72 h / Ambient temperature

With 2,6-dimethylpyridine; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; (CF₃SO₂)2; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)60843-2