Technology Process of β-chloroethyl p-methylthiophenyl ketone
There total 1 articles about β-chloroethyl p-methylthiophenyl ketone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-phenyl-thioether; 2-chloropropionyl chloride;
With
aluminum (III) chloride;
In
chloroform;
at 0 - 25 ℃;
With
water;
In
chloroform;
DOI:10.1016/j.bmcl.2010.06.155
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: bromine / dichloromethane / 0 °C
2.1: dihydrogen peroxide; sodium tungstate (VI) dihydrate / acetonitrile / 16 h / 20 - 60 °C
3.1: triethylamine / methanol / 3 h / 10 - 20 °C
4.1: zinc(II) chloride / methanol / 0.5 h / -40 °C
4.2: 4 h / -40 °C
5.1: triethylamine tris(hydrogen fluoride) / dichloromethane / 3 h / 85 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 40 °C / 912.06 Torr
7.1: triethylamine / dichloromethane / 2 h / -10 - 0 °C
8.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 15 °C
9.1: hydrogenchloride / water; ethanol / 8 h / 100 °C
10.1: triethylamine / methanol / 12 h / 50 °C
With
hydrogenchloride; sodium tungstate (VI) dihydrate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; bromine; methanesulfonyl chloride; triethylamine tris(hydrogen fluoride); triethylamine; zinc(II) chloride;
In
methanol; ethanol; dichloromethane; water; acetonitrile;
