Technology Process of (2,4-dihydroxy-5-(p-tolylamino)phenyl)(isoindolin-2-yl)methanone
There total 7 articles about (2,4-dihydroxy-5-(p-tolylamino)phenyl)(isoindolin-2-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 24h;
DOI:10.1016/j.bmcl.2014.03.100
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetic acid; bromine
2: thionyl chloride / 16 h / 20 °C
3: potassium carbonate / acetonitrile / 5 h / Reflux
4: water; sodium hydroxide / tetrahydrofuran / 2 h / 80 °C
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
6: bis(dibenzylideneacetone)-palladium(0); tri-tert-butyl phosphine; sodium t-butanolate / toluene / 23 h / Reflux; Inert atmosphere
7: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C
With
thionyl chloride; tri-tert-butyl phosphine; palladium 10% on activated carbon; water; hydrogen; bromine; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.100
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 16 h / 20 °C
2: potassium carbonate / acetonitrile / 5 h / Reflux
3: water; sodium hydroxide / tetrahydrofuran / 2 h / 80 °C
4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
5: bis(dibenzylideneacetone)-palladium(0); tri-tert-butyl phosphine; sodium t-butanolate / toluene / 23 h / Reflux; Inert atmosphere
6: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C
With
thionyl chloride; tri-tert-butyl phosphine; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.100
