(S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride

Base Information

• Chemical Name: (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride
• CAS No.: 1416800-02-6
• Molecular Formula: C₁₄H₁₀F₆N₂*ClH
• Molecular Weight: 356.698

Synonyms:(S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride

Chemical Property of (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride

Chemical Property:

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Technology Process of (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride

There total 2 articles about (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-2-methyl-N-((S)-(4-(trifluoromethyl)phenyl)-(3-(trifluoromethyl)pyridin-2-yl)methyl)propane-2-sulfinamide (1416800-01-5) → (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride (1416800-02-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

(S)-2-methyl-N-((S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)-pyridin-2-yl)methyl)propane-2-sulfinamide → (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride (1416800-02-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

6-bromo-1-oxo-2,3-dihydro-1H-isoindole (675109-26-9) + carbon monoxide (201230-82-2) + (S)-(4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)-methanamine hydrochloride (1416800-02-6) → C23H15F6N3O2 (1416797-49-3)

Guidance literature:

With sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 20 - 85 ℃; Inert atmosphere;

upstream raw materials:

(S)-2-methyl-N-((S)-(4-(trifluoromethyl)phenyl)-(3-(trifluoromethyl)pyridin-2-yl)methyl)propane-2-sulfinamide

Downstream raw materials:

(S)-1-(2-methoxypyrimidin-5-yl)-3-((4-(trifluoromethyl)-phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)urea

(S)-1-(4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-3-((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methyl)urea

C₂₃H₁₅F₆N₃O₂

(S)-5-(((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)-pyridin-2-yl)methyl)carbamoyl)picolinic acid 2,2,2-trifluoroacetate

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