C₂₆H₃₆N₂O₃

Base Information

• Chemical Name: C₂₆H₃₆N₂O₃
• CAS No.: 211430-53-4
• Molecular Formula: C₂₆H₃₆N₂O₃
• Molecular Weight: 424.583
• Mol file: 211430-53-4.mol

Synonyms:C₂₆H₃₆N₂O₃

Chemical Property of C₂₆H₃₆N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₆N₂O₃

There total 20 articles about C₂₆H₃₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C26H34N2O4 (211430-52-3) → C26H36N2O3 (211430-53-4)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether;

DOI:10.1016/S0040-4039(98)00797-7

Reference yield:

cyclohexanone-4-carboxylic acid ethyleneacetal (66500-55-8) → C26H36N2O3 (211430-53-4)

Guidance literature:

Multi-step reaction with 18 steps

1.1: diisopropylamine; BuLi / tetrahydrofuran; hexane / 1 h / 20 °C

1.2: 78 percent / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

2.2: 65 percent / benzene / 5 h / Heating

3.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

4.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

5.1: 92 percent / imidazole / dimethylformamide / 4.5 h / 20 °C

6.1: H₂ / 5 percent Pd/C / methanol / 3 h

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / 3.5 h / Heating

8.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C

9.1: 964 mg / tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 20 °C

10.1: 82 percent / diphenylphosphoryl azide; triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

11.1: 75 percent / H₂ / 5 percent Pd/C / methanol / 1.5 h

12.1: lithium hydroxide / H₂O / 0.67 h / 20 °C

13.1: 234 mg / diphenylphosphoryl azide; triethylamine / dimethylformamide / 1.5 h / 20 °C

14.1: 56 percent / sodium hydride / tetrahydrofuran / 1.5 h / 20 °C

15.1: lithium diisopropylamide / tetrahydrofuran / 0.33 h / -78 °C

15.2: 85 percent / tetrahydrofuran / 0.33 h / -78 °C

16.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

17.1: 14.1 mg / potassium tert-butoxide / tetrahydrofuran / 1 h / 0 °C

18.1: lithium aluminium hydride; aluminium chloride / diethyl ether / 1 h / 20 °C

With 1H-imidazole; dmap; lithium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; aluminium trichloride; diphenylphosphoranyl azide; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1016/S0040-4020(02)00436-2

Reference yield:

8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid (159638-73-0) → C26H36N2O3 (211430-53-4)

Guidance literature:

Multi-step reaction with 17 steps

1.1: diphenylphosphoryl azide; triethylamine / benzene / 0.5 h / Heating

1.2: 65 percent / benzene / 5 h / Heating

2.1: 94 percent / osmium tetroxide; N-methylmorpholine N-oxide / acetone; H₂O; 2-methyl-propan-2-ol / 5 h / 20 °C

3.1: 86 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 4 h / 20 °C

4.1: 92 percent / imidazole / dimethylformamide / 4.5 h / 20 °C

5.1: H₂ / 5 percent Pd/C / methanol / 3 h

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / 3.5 h / Heating

7.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C

8.1: 964 mg / tetrabutylammonium fluoride / tetrahydrofuran / 15 h / 20 °C

9.1: 82 percent / diphenylphosphoryl azide; triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

10.1: 75 percent / H₂ / 5 percent Pd/C / methanol / 1.5 h

11.1: lithium hydroxide / H₂O / 0.67 h / 20 °C

12.1: 234 mg / diphenylphosphoryl azide; triethylamine / dimethylformamide / 1.5 h / 20 °C

13.1: 56 percent / sodium hydride / tetrahydrofuran / 1.5 h / 20 °C

14.1: lithium diisopropylamide / tetrahydrofuran / 0.33 h / -78 °C

14.2: 85 percent / tetrahydrofuran / 0.33 h / -78 °C

15.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

16.1: 14.1 mg / potassium tert-butoxide / tetrahydrofuran / 1 h / 0 °C

17.1: lithium aluminium hydride; aluminium chloride / diethyl ether / 1 h / 20 °C

With 1H-imidazole; dmap; lithium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; aluminium trichloride; diphenylphosphoranyl azide; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1016/S0040-4020(02)00436-2

upstream raw materials:

C₂₆H₃₄N₂O₄

cyclohexanone-4-carboxylic acid ethyleneacetal

11-(tert-Butyl-dimethyl-silanyloxy)-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradecane

8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid