211430-52-3

Upstream product

• 211430-42-1 8-(2'-tert-butyldimethylsilyloxy-3'-tosyloxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane 
• 159638-81-0 Toluene-4-sulfonic acid 3-(8-benzyloxycarbonylamino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-hydroxy-propyl ester 
• 211430-43-2 Toluene-4-sulfonic acid 3-(8-amino-1,4-dioxa-spiro[4.5]dec-8-yl)-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester 
• 159638-80-9 8-(2',3'-dihydroxypropyl)-8-phenylmethoxycarbonylamino-1,4-dioxaspiro[4.5]decane 
• 227019-38-7 [11-(tert-Butyl-dimethyl-silanyloxy)-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradec-9-yl]-acetic acid ethyl ester 
• 211430-46-5 dispiro[3-azido-1-ethoxycarbonylmethylpyrrolidine-5,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 159638-79-6 8-phenylmethoxycarbonylamino-8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane 
• 211430-45-4 dispiro[1,3-dioxolane-2,1'-cyclohexane-4',5''-(1-ethoxycarbonylmethyl-3-hydroxypyrrolidine)] 
• 211430-47-6 dispiro[3-amino-1-ethoxycarbonylmethylpyrrolidine-5,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 211430-50-1 dispiro[1,3-dioxolane-2,1'-cyclohexane-4',7''-(4-methyl-1,4-diazabicyclo[3.2.1]octan-3-one)] 
• 211430-48-7 (11-Amino-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradec-9-yl)-acetic acid 
• 211430-49-8 dispiro[1,4-diazabicyclo[3.2.1]octan-3-one-7,1'-cyclohexane-4',2''-1,3-dioxolane] 
• 159638-73-0 8-(2'-propenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid 
• 211430-44-3 11-(tert-Butyl-dimethyl-silanyloxy)-1,4-dioxa-9-aza-dispiro[4.2.4.2]tetradecane 

Downstream Products

• 211430-53-4 C₂₆H₃₆N₂O₃ 

Relevant academic research and scientific papers

Total synthesis of antimuscarinic alkaloid, (±)-TAN1251A

The total synthesis of (±)-TAN1251A possessing an antimuscarinic activity was achieved. Carboxylic acid (1) was converted into carbamate (3) through a sequence of alkylation and Curtius rearrangement. After a few functional group interconversions of 3, the corresponding amine (9) was converted into an azaspiro molecule (18) through cyclization and installation of a C2 unit. Hydrolysis of 18 followed by lactam formation afforded tricyclic compound (20). Coupling of 20 with aldehyde (22) gave two epimeric adducts, (23A) and (23B), which were converted into TAN1251A by four steps.

Total synthesis of (±)-TAN1251A

The first synthesis of novel type alkaloid (±)-TAN1251A possessing an antimuscarinic activity was achieved.