1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

Base Information

Chemical Name:1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile
CAS No.:144791-32-2
Molecular Formula:C₂₁H₁₉ClFN₃
Molecular Weight:367.853
Hs Code.:

Synonyms:1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

Chemical Property:

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Technology Process of 1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

There total 4 articles about 1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107-14-2
chloroacetonitrile

: 139774-04-2
6-chloro-1-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indole

: 144791-32-2
1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

Guidance literature:: With triethylamine; In various solvent(s); at 60 - 70 ℃; for 2h;
DOI:10.1021/jm00104a006

Reference yield:

: 40064-34-4
piperidine-4,4-diol hydrochloride

: 144791-32-2
1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid, acetic acid / 0.5 h / Heating

2: H₂ / PtO₂ / ethanol; acetic acid / 20 h / 1520 - 2280 Torr

3: 100 percent / Et₃N / various solvent(s) / 2 h / 60 - 70 °C

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In ethanol; acetic acid;
DOI:10.1021/jm00104a006

Reference yield:

: 139774-27-9
6-chloro-1-(4-fluorophenyl)-1H-indole

: 144791-32-2
1-<4-<6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl>-1-piperidinyl>acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid, acetic acid / 0.5 h / Heating

2: H₂ / PtO₂ / ethanol; acetic acid / 20 h / 1520 - 2280 Torr

3: 100 percent / Et₃N / various solvent(s) / 2 h / 60 - 70 °C

With hydrogen; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; In ethanol; acetic acid;
DOI:10.1021/jm00104a006