5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

Base Information

Chemical Name:5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one
CAS No.:1354030-54-8
Molecular Formula:C₂₂H₂₅Cl₂N₃O₂
Molecular Weight:434.365
Hs Code.:

Synonyms:5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

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Chemical Property of 5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

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Technology Process of 5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

There total 10 articles about 5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1354030-53-7
C₁₁H₁₃BrN₂O₂

: 1354030-49-1
4-(2,3-dichlorophenyl)piperidine hydrochloride

: 1354030-54-8
5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

Guidance literature:: C₁₁H₁₃BrN₂O₂; With sodium iodide; In acetonitrile; for 0.5h; Reflux;

4-(2,3-dichlorophenyl)piperidine hydrochloride; With potassium carbonate; In acetonitrile; Reflux;

Reference yield:

: 110-86-1
pyridine

: 1354030-54-8
5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide / tetrahydrofuran / -10 - 0 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / -30 - -20 °C

2.2: 0 - 20 °C

3.1: hydrogen / Wilkinson's catalyst / toluene / 6 h / 70 °C / 2068.65 Torr

4.1: hydrogenchloride / tetrahydrofuran / 3 h / Reflux

5.1: sodium iodide / acetonitrile / 0.5 h / Reflux

5.2: Reflux

With hydrogenchloride; copper(l) iodide; hydrogen; isopropylmagnesium chloride; sodium iodide; Wilkinson's catalyst; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 948838-40-2
C₁₃H₁₂NO₂⁽¹⁺⁾*Cl^(1-)

: 1354030-54-8
5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -30 - -20 °C

1.2: 0 - 20 °C

2.1: hydrogen / Wilkinson's catalyst / toluene / 6 h / 70 °C / 2068.65 Torr

3.1: hydrogenchloride / tetrahydrofuran / 3 h / Reflux

4.1: sodium iodide / acetonitrile / 0.5 h / Reflux

4.2: Reflux

With hydrogenchloride; hydrogen; isopropylmagnesium chloride; sodium iodide; Wilkinson's catalyst; In tetrahydrofuran; toluene; acetonitrile;