(S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate

Base Information

• Chemical Name: (S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate
• CAS No.: 1045709-90-7
• Molecular Formula: C₇H₈O₃S*C₃₆H₄₅N₃O₁₀
• Molecular Weight: 851.972
• Mol file: 1045709-90-7.mol

Synonyms:(S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate

Chemical Property of (S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate

There total 1 articles about (S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate (1045709-88-3) + toluene-4-sulfonic acid (104-15-4) → (S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate (1045709-90-7)

Guidance literature:

In ethanol; ethyl acetate; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm800111u

Reference yield: 90.0%

(S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate (1045709-90-7) + N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid (108466-89-3) → C47H64N4O15 (1246261-24-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/bc3003919

Reference yield: 52.5%

(S)-5-(3-((S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-yl)ureido)-6-((4-methoxybenzyl)oxy)-6-oxohexan-1-aminium tosylate (1045709-90-7) → 2-{3-[1-p-methoxybenzylcarboxylate-(5-aminopentyl)]ureido}-di-p-methoxybenzyl pentanedioate (1045709-74-7)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Inert atmosphere;

DOI:10.1021/jm800111u

upstream raw materials:

(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

toluene-4-sulfonic acid

Downstream raw materials:

C₅₆H₇₀N₆O₁₁

2-{3-[1-p-methoxybenzylcarboxylate-(5-aminopentyl)]ureido}-di-p-methoxybenzyl pentanedioate

C₄₇H₆₄N₄O₁₅