Technology Process of (10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate
There total 8 articles about (10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxybenzyl N6-(tert-butoxycarbonyl)-L-lysinate;
With
bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.666667h;
Inert atmosphere;
bis(4-methoxybenzyl) L-glutamate;
In
dichloromethane;
for 0.666667h;
DOI:10.1002/chem.201903390
- Guidance literature:
-
bis(trichloromethyl) carbonate; (S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-aminium chloride;
With
triethylamine;
In
dichloromethane;
at -77 - 20 ℃;
Inert atmosphere;
(S)-2-amino-6-tert-butoxycarbonylaminohexanoic acid 4-methoxybenzyl ester;
In
dichloromethane;
Inert atmosphere;
DOI:10.1021/jm800111u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere
2.1: piperidine / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
3.2: 2 h / 0 - 20 °C / Inert atmosphere
With
piperidine; caesium carbonate; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1013715
