(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

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Chemical Name:(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate
CAS No.:1045709-88-3
Molecular Formula:C₄₁H₅₃N₃O₁₂
Molecular Weight:779.885
Hs Code.:

Synonyms:(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

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Chemical Property of (10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

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Technology Process of (10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

There total 8 articles about (10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 4-methoxybenzyl N₆-(tert-butoxycarbonyl)-L-lysinate

: bis(4-methoxybenzyl) L-glutamate

: 1045709-88-3
(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

Guidance literature:: 4-methoxybenzyl N₆-(tert-butoxycarbonyl)-L-lysinate; With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

bis(4-methoxybenzyl) L-glutamate; In dichloromethane; for 0.666667h;
DOI:10.1002/chem.201903390

Reference yield: 62.3%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1045709-85-0
(S)-2-amino-6-tert-butoxycarbonylaminohexanoic acid 4-methoxybenzyl ester

: 68709-64-8
(S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-aminium chloride

: 1045709-88-3
(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

Guidance literature:: bis(trichloromethyl) carbonate; (S)-1,5-bis((4-methoxybenzyl)oxy)-1,5-dioxopentan-2-aminium chloride; With triethylamine; In dichloromethane; at -77 - 20 ℃; Inert atmosphere;

(S)-2-amino-6-tert-butoxycarbonylaminohexanoic acid 4-methoxybenzyl ester; In dichloromethane; Inert atmosphere;
DOI:10.1021/jm800111u

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1045709-88-3
(10S,14S)-tris(4-methoxybenzyl) 2,2-dimethyl-4,12-dioxo-3-oxa-5,11,13-triazahexadecane-10,14,16-tricarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2.1: piperidine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

With piperidine; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1013715