Technology Process of 3-benzylcarbamoyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester
There total 10 articles about 3-benzylcarbamoyl-3-phenyl-pyrrolidine-1-carboxylic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrahydrofuran / 2 h / -78 - 20 °C
2: BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
3: 84 percent / NMO / OsO4 / H2O; tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / Heating
4: 94 percent / BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
5: 88 percent / Jones reagent / acetone / 0.17 h / at ice bath
6: DCC / tetrahydrofuran / 6 h / Heating
With
N-methyl-2-indolinone; jones reagent; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide;
osmium(VIII) oxide;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2005.10.015
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Et3N / CH2Cl2 / 1 h / 20 °C
2: Jones reagent / acetone / 0.25 h / at ice bath
3: tetrahydrofuran / 2 h / -78 - 20 °C
4: BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
5: 84 percent / NMO / OsO4 / H2O; tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / Heating
6: 94 percent / BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
7: 88 percent / Jones reagent / acetone / 0.17 h / at ice bath
8: DCC / tetrahydrofuran / 6 h / Heating
With
N-methyl-2-indolinone; jones reagent; boron trifluoride diethyl etherate; triethylamine; dicyclohexyl-carbodiimide;
osmium(VIII) oxide;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2005.10.015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
2: 84 percent / NMO / OsO4 / H2O; tetrahydrofuran; 2-methyl-propan-2-ol / 2 h / Heating
3: 94 percent / BF3*Et2O / CH2Cl2 / 0.25 h / 20 °C
4: 88 percent / Jones reagent / acetone / 0.17 h / at ice bath
5: DCC / tetrahydrofuran / 6 h / Heating
With
N-methyl-2-indolinone; jones reagent; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide;
osmium(VIII) oxide;
In
tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2005.10.015