3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon)

Base Information

• Chemical Name: 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon)
• CAS No.: 5863-63-8
• Molecular Formula: C₃₁H₄₆N₂O₅S
• Molecular Weight: 558.783
• Mol file: 5863-63-8.mol

Synonyms:3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon)

Chemical Property of 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon)

There total 5 articles about 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

12-oxolithocholic acid (5130-29-0,83830-81-3) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon) (5863-63-8)

Guidance literature:

With acetic acid; at 20 ℃; for 12h; Time;

Reference yield:

3α-benzoyloxy-12α-hydroxy-5β-cholane-24-ic acid methyl ester (5969-28-8) → 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon) (5863-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) aq. CrO₃, AcOH, (ii) H₂SO₄

2: KOH / methanol

3: acetic acid

With potassium hydroxide; In methanol; acetic acid;

DOI:10.1016/0040-4020(66)80079-0

Reference yield:

Deoxycholic acid (83-44-3) → 3α-Hydroxy-12-keto-cholansaeure-(p-toluolsulfonsaeure-hydrazon) (5863-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) HCl, (ii) /BRN= 471389/, Py

2: (i) aq. CrO₃, AcOH, (ii) H₂SO₄

3: KOH / methanol

4: acetic acid

With potassium hydroxide; In methanol; acetic acid;

DOI:10.1016/0040-4020(66)80079-0

upstream raw materials:

toluene-4-sulfonic acid hydrazide

3α-benzoyloxy-12α-hydroxy-5β-cholane-24-ic acid methyl ester

Deoxycholic acid

3α-benzoyloxy-5β-cholane-12-one-24-ic acid methyl ester

Downstream raw materials:

Lithocholic acid