methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate
CAS No.:1428306-05-1
Molecular Formula:C₂₄H₂₅N₇O₄
Molecular Weight:475.507
Hs Code.:

Synonyms:methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

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Chemical Property of methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

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Technology Process of methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

There total 9 articles about methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428306-03-9
C₂₉H₃₃N₇O₆

: 1428306-05-1
methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 4h;
DOI:10.1021/jm301882a

Reference yield:

: 864076-03-9
4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

: 1428306-05-1
methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

2.1: 1,4-dioxane / Alkaline conditions

3.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 5 h

4.1: hydrogenchloride / 1,4-dioxane / 4 h

With hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm301882a

Reference yield:

: 1196-90-3
4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 1428306-05-1
methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 6 h / 20 °C

4.1: 1,4-dioxane / Alkaline conditions

5.1: benzotriazol-1-ol; diisopropyl-carbodiimide / dichloromethane / 5 h

6.1: hydrogenchloride / 1,4-dioxane / 4 h

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; diisopropyl-carbodiimide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling;
DOI:10.1021/jm301882a