4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid
CAS No.:864076-03-9
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Suppliers and Price of 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

There total 5 articles about 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 864076-02-8
methyl 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylate

: 864076-03-9
4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 6h;
DOI:10.1021/jm301882a

Reference yield:

: 96-54-8
N-Methylpyrrole

: 864076-03-9
4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 6 h / -10 - 20 °C

3.1: sodium methylate / 0.5 h / Reflux

3.2: pH 2

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

5.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm301882a

Reference yield:

: 184643-69-4
1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one

: 864076-03-9
4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / 0.5 h / Reflux

1.2: pH 2

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

3.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/jm301882a