2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid

Base Information

• Chemical Name: 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid
• CAS No.: 1006037-08-6
• Molecular Formula: C₁₅H₁₃F₃O₂S
• Molecular Weight: 314.328
• Mol file: 1006037-08-6.mol

Synonyms:2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid

Chemical Property of 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid

There total 5 articles about 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene (1006037-07-5) + carbon dioxide (124-38-9,18923-20-1) → 2,5-dimethyl-3-[4-(trifluoromethyl)benzyl]thiophene (1006037-09-7) + 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid (1006037-08-6)

Guidance literature:

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tert-butyl methyl ether; at -65 - -58 ℃; for 1.5h;

carbon dioxide; In tert-butyl methyl ether; at -60 - -54 ℃; for 1.5h;

With hydrogenchloride; water; In tert-butyl methyl ether; at -25 ℃; for 0.0833333h;

Reference yield: 79.0%

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene (1006037-07-5) + carbon dioxide (124-38-9,18923-20-1) → 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid (1006037-08-6)

Guidance literature:

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tert-butyl methyl ether; at -65 - -55 ℃; Inert atmosphere; Large scale reaction;

carbon dioxide; In tert-butyl methyl ether; at -55 ℃; for 3h; Inert atmosphere; Large scale reaction;

DOI:10.1021/jo1004197

Reference yield:

carbon dioxide (124-38-9,18923-20-1) → 2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid (1006037-08-6)

Guidance literature:

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene; With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; diethyl ether; hexane; at -78 - 0 ℃; for 1.75h;

With hydrogenchloride; water; ammonium chloride; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

carbon dioxide

3-bromo-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene

Downstream raw materials:

methyl 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate

C₁₅H₁₂ClF₃OS

N-[1-(4-cyanophenyl)cyclopropyl]-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxamide