Chemical Property of N-Fmoc-8-aminooctanoic acid
Chemical Property:
- Vapor Pressure:1.9E-15mmHg at 25°C
- Melting Point:118-119 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
- Refractive Index:1.648
- Boiling Point:597.73 °C at 760 mmHg
- PKA:4.77±0.10(Predicted)
- Flash Point:315.296 °C
- PSA：75.63000
- Density:1.174 g/cm3
- LogP:5.34120
- Storage Temp.:2-8°C
- XLogP3:4.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:11
- Exact Mass:381.19400834
- Heavy Atom Count:28
- Complexity:487
- Purity/Quality:
-
97% *data from raw suppliers
Fmoc-8-aminocaprylic acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCCCC(=O)O
-
Description
N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
