Technology Process of 5-phenyl-N-tosylpiperidin-2-one
There total 6 articles about 5-phenyl-N-tosylpiperidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol102536s
- Guidance literature:
-
Multi-step reaction with 5 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere; Darkness
2: trifluoroacetic acid / dichloromethane / Inert atmosphere
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
4: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
5: 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; di-isopropyl azodicarboxylate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
1: Mitsunobu reaction / 4: Dess-Martin oxidation;
DOI:10.1021/ol102536s
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
2: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
3: 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
2: Dess-Martin oxidation;
DOI:10.1021/ol102536s
