(S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester

Base Information

• Chemical Name: (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester
• CAS No.: 943148-40-1
• Molecular Formula: C₁₆H₂₂INO₄
• Molecular Weight: 419.259

Synonyms:(S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester

Chemical Property of (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-4-iodo-L-phenylalanine ethyl ester 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester

There total 1 articles about (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) → (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester (943148-40-1,639495-97-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02911

Reference yield: 87.0%

(S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester (943148-40-1,639495-97-9) + phosphonic acid diethyl ester (762-04-9) → (S)-2-tert-butoxycarbonylamino-3-[4-(diethoxy-phosphoryl)-phenyl]-propionic acid ethyl ester (943148-41-2)

Guidance literature:

With TEA; (tetrakistriphenylphosphine)Pd⁽⁰⁾; In acetonitrile; at 72 ℃; for 20h;

DOI:10.1016/j.tetlet.2007.04.027

Reference yield: 62.0%

di-tert-butyl phosphite (13086-84-5) + (S)-2-tert-butoxycarbonylamino-3-(4-iodo-phenyl)-propionic acid ethyl ester (943148-40-1,639495-97-9) → C24H40NO7P (943148-42-3)

Guidance literature:

With TEA; (tetrakistriphenylphosphine)Pd⁽⁰⁾; In acetonitrile; at 70 ℃; for 40h;

DOI:10.1016/j.tetlet.2007.04.027

upstream raw materials:

ethanol

N-Boc-4-I-Phe-OH

Downstream raw materials:

(S)-2-tert-butoxycarbonylamino-3-[4-(diethoxy-phosphoryl)-phenyl]-propionic acid ethyl ester

C₂₄H₄₀NO₇P

C₂₆H₂₆NO₇P

C₃₃H₃₂NO₇P

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