4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

Base Information

Chemical Name:4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile
CAS No.:1449474-14-9
Molecular Formula:C₁₈H₁₆ClFN₄O
Molecular Weight:358.803
Hs Code.:

Synonyms:4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

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Chemical Property of 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

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Technology Process of 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

There total 3 articles about 4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: C₂₃H₂₄ClFN₄O₃

: 1449474-14-9
4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

Guidance literature:: C₂₃H₂₄ClFN₄O₃; With acetic acid; at 40 ℃; for 18h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield:

: 4144-02-9
O-methyl-L-threonine

: 1449474-14-9
4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 18 h / 0 - 20 °C

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 0 °C

2.2: 18 h / 50 °C

3.1: acetic acid / 18 h / 40 °C

3.2: 3 h / 20 °C

With 4-methyl-morpholine; sodium hydrogencarbonate; acetic acid; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1449476-26-9
4'-amino-2'-chloro-3-fluoro-3'-nitrobiphenyl-4-carbonitrile

: 1449474-14-9
4-{2-[(1R,2R)-1-amino-2-methoxypropyl]-4-chloro-1H-benzimidazol-5-yl}-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; zinc / tetrahydrofuran; water / 1 h / 0 - 20 °C

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 2 h / 0 °C

2.2: 18 h / 50 °C

3.1: acetic acid / 18 h / 40 °C

3.2: 3 h / 20 °C

With 4-methyl-morpholine; acetic acid; HATU; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide;