2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Base Information

Chemical Name:2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid
CAS No.:1440546-93-9
Molecular Formula:C₃₉H₄₇N₃O₉
Molecular Weight:701.817
Hs Code.:

Synonyms:2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Suppliers and Price of 2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

There total 16 articles about 2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 1440546-88-2
ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

: 1440546-93-9
2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Guidance literature:: With water; In tetrahydrofuran; methanol; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol401197n

Reference yield:

: 165190-62-5
4-(benzyloxy)-2-bromo-1-nitrobenzene

: 1440546-93-9
2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 50 °C / Inert atmosphere

2.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

4.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

4.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

8.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

With copper(l) iodide; tin(II) chloride dihdyrate; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol401197n

Reference yield:

: 215712-11-1
4-(benzyloxy)-2-bromoaniline

: 1440546-93-9
2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3-diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

1.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

3.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

7.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

With copper(l) iodide; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol401197n