ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

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Chemical Name:ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate
CAS No.:1440546-88-2
Molecular Formula:C₄₁H₅₁N₃O₉
Molecular Weight:729.871
Hs Code.:

Synonyms:ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

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Chemical Property of ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

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Technology Process of ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

There total 14 articles about ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165190-62-5
4-(benzyloxy)-2-bromo-1-nitrobenzene

: 1440546-88-2
ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 50 °C / Inert atmosphere

2.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

2.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

4.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

4.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; tin(II) chloride dihdyrate; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol401197n

Reference yield:

: 215712-11-1
4-(benzyloxy)-2-bromoaniline

: 1440546-88-2
ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

1.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

3.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol401197n

Reference yield:

: 138490-94-5
2-iodoisovanillin

: 1440546-88-2
ethyl2-((4-(benzyloxy)-2-((6-((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)-2,3diisobutoxyphenyl)ethynyl)phenyl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; aluminum (III) chloride / dichloromethane / 20.08 h / 0 °C / Inert atmosphere; Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 72 h / 50 °C / Inert atmosphere

3.1: potassium permanganate / water; acetone / 36 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

4.2: 2 h / 0 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; copper(l) iodide; triethylamine / toluene / 0.08 h / 20 °C / Inert atmosphere

5.2: 1 h / 110 °C / Inert atmosphere; Microwave irradiation

6.1: water / water; methanol; tetrahydrofuran / 20 °C / Inert atmosphere

7.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; aluminum (III) chloride; potassium permanganate; copper(l) iodide; water; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ol401197n