2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

Base Information

Chemical Name:2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester
CAS No.:133129-66-5
Molecular Formula:C₂₂H₂₈O₈
Molecular Weight:420.46
Hs Code.:

Synonyms:2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

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Chemical Property of 2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

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Technology Process of 2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

There total 7 articles about 2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2033-89-8
3,4-dimethoxyphenol

: 133129-66-5
2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.5 h, 2.) a) 0 deg C, 0.5 h, b) RT, 2.5 h

2: 1.) n-BuLi / 1.) Et₂O, TMEDA, hexane, 0 deg C, 1 h, 2.) from 0 deg C to RT

3: (COCl)2, DMF / CH₂Cl₂ / 1 h / 0 °C

4: CH₂Cl₂ / 1.5 h / 0 °C

5: 83 percent / K₂CO₃ / acetone / 12 h / Heating

6: 88 percent / 0.25 h

7: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) from 0 deg C to RT, 1 h

8: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) from -78 deg C to 0 deg C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; sodium hydride; potassium carbonate; ozone; N,N-dimethyl-formamide; In dichloromethane; acetone;
DOI:10.1021/jm00109a013

Reference yield:

: 63147-21-7
2,3-dimethoxy-6-hydroxybenzoic acid, phenylmethyl ester

: 133129-66-5
2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / K₂CO₃ / acetone / 12 h / Heating

2: 88 percent / 0.25 h

3: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) from 0 deg C to RT, 1 h

4: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) from -78 deg C to 0 deg C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; ozone; In acetone;
DOI:10.1021/jm00109a013

Reference yield:

: 133129-57-4
2,3-dimethoxy-6-(methoxymethyl)benzoic acid

: 133129-66-5
2,3-dimethoxy-5-(2-hydroxyethyl)-6-<(2-methoxyethoxy)methoxy>benzoic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: (COCl)2, DMF / CH₂Cl₂ / 1 h / 0 °C

2: CH₂Cl₂ / 1.5 h / 0 °C

3: 83 percent / K₂CO₃ / acetone / 12 h / Heating

4: 88 percent / 0.25 h

5: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) from 0 deg C to RT, 1 h

6: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) from -78 deg C to 0 deg C

With sodium tetrahydroborate; oxalyl dichloride; sodium hydride; potassium carbonate; ozone; N,N-dimethyl-formamide; In dichloromethane; acetone;
DOI:10.1021/jm00109a013