4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER

Base Information

• Chemical Name: 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER
• CAS No.: 252720-32-4
• Molecular Formula: C19H26N2O6
• Molecular Weight: 378.425
• Hs Code.: 29333990
• Mol file: 252720-32-4.mol

Synonyms:1-[(Benzyloxy)carbonyl]-4-[(tert-butoxycarbonyl)amino]piperidine-4-carboxylicacid;

Chemical Property of 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 556.46 °C at 760 mmHg
• PKA: 3.86±0.20(Predicted)
• Flash Point: 290.337 °C
• PSA: 105.17000
• Density: 1.264 g/cm³
• LogP: 3.09590
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-tert-Butoxycarbonylaminopiperidine-1,4-dicarboxylic acid monobenzyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER

There total 1 articles about 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-Amino-1-benzyloxycarbonyl-piperidine-4-carboxylic acid, hydrochloride → 1-((benzyloxy)carbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid (252720-32-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 72h; Inert atmosphere;

Reference yield: 96.0%

1-((benzyloxy)carbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid (252720-32-4) + methyl iodide (74-88-4) → 1-benzyl 4-methyl 4-((tert-butoxycarbonyl)amino)piperidine-1,4-dicarboxylate

Guidance literature:

1-((benzyloxy)carbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid; With caesium carbonate; In acetonitrile; for 0.166667h; Cooling with ice;

methyl iodide; In acetonitrile; at 20 ℃; for 1h;

Reference yield: 95.0%

methyl(propargyl)amine (35161-71-8) + 1-((benzyloxy)carbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid (252720-32-4) → benzyl 4-((tert-butoxycarbonyl)amino)-4-(methyl(prop-2-yn-1-yl)carbamoyl)piperidine-1-carboxylate

Guidance literature:

1-((benzyloxy)carbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl(propargyl)amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/acs.orglett.0c02070

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

t-butyl 1-benzyloxycarbonyl-4-cyclohexylmethylaminocarbonylpiperidin-4-ylcarbamate

4-tert-Butoxycarbonylamino-4-(4-isopropyl-phenylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester

4-[(tert-butyloxycarbonyl)amino]-4-(methoxycarbonyl)piperidine

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