2-Ethyl-3-methylbenzofuran

Base Information

• Chemical Name: 2-Ethyl-3-methylbenzofuran
• CAS No.: 80079-25-0
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.216
• Hs Code.: 2932999099
• Mol file: 80079-25-0.mol

Synonyms:2-Ethyl-3-methylbenzofuran;Benzofuran, 2-ethyl-3-methyl-

Chemical Property of 2-Ethyl-3-methylbenzofuran

Chemical Property:

• Refractive Index: 1.566
• Boiling Point: 239.6 °C at 760 mmHg
• Flash Point: 97.3 °C
• PSA: 13.14000
• Density: 1.03 g/cm³
• LogP: 3.30360
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethyl-3-methylbenzofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-3-methylbenzofuran

There total 12 articles about 2-Ethyl-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-pentanone O-phenyloxime (553380-60-2) → 2-ethyl-3-methylbenzofuran (80079-25-0)

Guidance literature:

With dmap; trifluoroacetyl triflate; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1002/ejoc.200601001

Reference yield: 87.0%

3-Phenoxy-pentanon-(2) (91970-24-0) → 2-ethyl-3-methylbenzofuran (80079-25-0)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 10 ℃;

DOI:10.1177/1747519820907244

Reference yield: 71.0%

2'-propanoyloxyacetophenone (97139-96-3) → 2-ethyl-3-methylbenzofuran (80079-25-0)

Guidance literature:

With titanium(III) chloride; zinc; In tetrahydrofuran; Inert atmosphere; Reflux;

upstream raw materials:

2-ethylbenzofuran-3-carbaldehyde

phenoxyamine hydrochloride

pentan-3-one

3-pentanone O-phenyloxime

Refernces

• 1、 Ma, Lin,Ma, Zhanwei,Zhang, Min,Zhou, Min. "Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent". . p. 426 - 436. Retrieved 2020/03/23.
• 2、 Contiero, Fanny,Jones, Kevin M.,Matts, Edward A.,Porzelle, Achim,Tomkinson, Nicholas C.O.. "Direct preparation of benzofurans from O-arylhydroxylamines". experimental part. p. 3003 - 3006. Retrieved 2010/03/03.