97139-96-3

Upstream product

• 79-03-8 propionyl chloride 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1234512-63-0 3⁽⁵⁾-(2-hydroxyphenyl)-5⁽³⁾-ethylpyrazole 
• 80079-25-0 2-ethyl-3-methylbenzofuran 
• 146297-88-3 2'-propanoyloxy-2-bromoacetophenone 
• 14736-30-2 2-ethyl-4H-chromen-4-one 
• 35115-15-2 2-(propionylacetyl)phenol 

Relevant academic research and scientific papers

Short communication: Titanium-induced synthesis of benzofurans

Ketoesters derived from the acylation of o-hydroxyacetophenone with aliphatic as well as aromatic acid chlorides undergo intramolecular cyclization in the presence of low-valent titanium to afford benzofurans in good yields. The reduction of titanium trichloride with dry zinc powder in refluxing THF takes place in the presence of the ketoester which simultaneously cyclizes as the titanium catalyst is formed, rendering the pre-reduction of titanium trichloride in a separate step unnecessary.

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2

Human lipoxygenase (hLO) isozymes have been implicated in a number of disease states and have attracted much attention with respect to their inhibition. One class of inhibitors, the flavonoids, have been shown to be potent lipoxygenase inhibitors but their study has been restricted to those compounds found in nature, which have limited structural variability. We have therefore carried out a comprehensive study to determine the structural requirements for flavonoid potency and selectivity against platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. We conclude from this study that catechols are essential for high potency, that isoflavones and isoflavanones tend to select against 12-hLO, that isoflavans tend to select against 15-hLO-1, but few flavonoids target 15-hLO-2.

A new metal complex promoted system for highly selective synthesis of 4H-chromen-4-ones (chromones)

Co(III)(salpr)(OH), a six coordinate cobalt Schiff base complex, promotes the highly selective conversion of 1-(o-hydroxyaryl)-1,3-diketones to 4H-chromen-4-ones under neutral conditions.