Technology Process of 2-Ethyl-5-methylbenzofuran
There total 4 articles about 2-Ethyl-5-methylbenzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methylbenzofuran;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
ethyl bromide;
In
tetrahydrofuran; hexane;
at 20 ℃;
Inert atmosphere;
Schlenk technique;
Cooling;
DOI:10.1002/anie.202103910
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: polyphosphoric acid / toluene / 16 h / 110 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere; Schlenk technique
2.2: 20 °C / Inert atmosphere; Schlenk technique; Cooling
With
n-butyllithium;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1002/anie.202103910
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere; Schlenk technique
2.1: polyphosphoric acid / toluene / 16 h / 110 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere; Schlenk technique
3.2: 20 °C / Inert atmosphere; Schlenk technique; Cooling
With
n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.202103910
