2-(2-Phenylethyl)morpholine

Base Information

Chemical Name:2-(2-Phenylethyl)morpholine
CAS No.:58039-64-8
Molecular Formula:C₁₂H₁₇NO
Molecular Weight:191.273
Hs Code.:
European Community (EC) Number:873-336-6
Wikidata:Q107854849

Synonyms:2-(2-phenylethyl)morpholine;58039-64-8;2-Phenethylmorpholine;SCHEMBL78044;2-(beta-phenylethyl)morpholine;TXIWKJLQPACJEW-UHFFFAOYSA-N;MFCD09055010;AKOS006331153;DA-04691;NS-01805;CS-0453863;EN300-135402;G65393;F2148-1688;Z1198184701;2-(2-Phenylethyl)morpholine;Morpholine, 2-(2-phenylethyl)-;(RS)-2-(2-Phenylethyl)morpholine

Suppliers and Price of 2-(2-Phenylethyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2-Phenylethyl)morpholine
100mg
$ 165.00

Medical Isotopes, Inc.
2-(2-Phenylethyl)morpholine
1 g
$ 2200.00

AK Scientific
2-(2-Phenylethyl)morpholine
5g
$ 2669.00

AK Scientific
2-(2-Phenylethyl)morpholine
1g
$ 985.00

AK Scientific
2-(2-Phenylethyl)morpholine
250mg
$ 538.00

AK Scientific
2-(2-Phenylethyl)morpholine
100mg
$ 407.00

Total 5 raw suppliers

Chemical Property of 2-(2-Phenylethyl)morpholine

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:191.131014166
Heavy Atom Count:14
Complexity:154

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Phenylethyl)morpholine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC(CN1)CCC2=CC=CC=C2
Uses 2-(2-Phenylethyl)morpholine is used to prepare 2,4-disubstituted morpholines that bind at at human D4 dopamine receptors.

Technology Process of 2-(2-Phenylethyl)morpholine

There total 12 articles about 2-(2-Phenylethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (R)-2-((R)-2-phenethylmorpholino)-2-phenylethan-1-ol

: 58039-64-8
2-[2-phenylethyl]-morpholine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h;
DOI:10.1002/jhet.3657

Reference yield:

: 58040-19-0
4-benzyl-2-phenethylmorpholine

: 58039-64-8
2-[2-phenylethyl]-morpholine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol301203z

Reference yield:

: 18328-11-5
3-benzyl propionaldehyde

: 58039-64-8
2-[2-phenylethyl]-morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: N-chloro-succinimide; rac-Pro-OH / dichloromethane / 0 - 20 °C

2: sodium tetrahydroborate / methanol / 0.5 h / -20 - 20 °C

3: 2,6-dimethylpyridine / dichloromethane / 0.5 h / -78 °C

4: dichloromethane / 4 h / -78 - 20 °C

5: potassium tert-butylate / acetonitrile / -20 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; N-chloro-succinimide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; rac-Pro-OH; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol301203z