288570-67-2

Basic information

• Product Name: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate
• Synonyms: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate
• CAS NO: 288570-67-2
• Molecular Weight: 290.132
• Mol File: 288570-67-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate(288570-67-2)
• EPA Substance Registry System: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate(288570-67-2)

Safety Data

• Hazardous Substances Data: 288570-67-2(Hazardous Substances Data)

Upstream product

• 321430-28-8 3-fluorophenylcarbamic acid 2-methylpropyl ester 
• 372-19-0 meta-fluoroaniline 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 288570-70-7 2-methylpropyl [3-fluoro-4-(tetrahydro-4-hydroxy-2H-thiopyran-4-yl)phenyl]carbamate 
• 444335-16-4 (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one 
• 288570-76-3 cis-2-methylpropyl [3-fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]carbamate 
• 288570-80-9 trans-[3-fluoro-4-(1-oxo-tetrahydrothiopyran-4-yl)phenyl]carbamic acid isobutyl ester 
• 288570-82-1 2-methylpropyl [4-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl]carbamate 
• 288570-74-1 2-methylpropyl [4-(3,6-dihydro-1-oxido-2H-thiopyran-4-yl)-3-fluorophenyl]carbamate 
• 288570-78-5 2-methylpropyl [3-fluoro-4-(tetrahydro-2H-thiopyran-4-yl)phenyl]carbamate 
• 288570-72-9 [4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]carbamic acid 2-methylpropyl ester 

Relevant articles and documents

Novel oxazolidinone-quinolone hybrid antimicrobials

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.

2-Fluoro-(oxid-thiopyran-4-yl)benzene derivatives

Compounds that can be used in the synthesis of cyclic sulfur-containing oxazolidinone antibacterial agents include2-Methylpropyl [4-(3,6-dihydro-1,1-dioxido-2H-thiopyran-4-yl)-3-fluorophenyl]carbamate,4(R)-trans-[3-[3-Fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl 3-nitrobenzenesulfonate,1α,4β(S)-N-[[3-[3-Fluoro-4-(tetrahydro-1-oxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]propanarnide monohydrate,4(R)-3-[3-Fluoro-4-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)phenyl]-5-(hydroxymethyl)-2-oxazolidinone,4(R)-[3-[3-Fluoro-4-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl 3-nitrobenzenesulfonate.

Stereodivergent synthesis of sulfoxide-containing oxazolidinone antibiotics

Carbamate 5 was prepared under mild conditions via a novel metal-halogen exchange procedure without competing benzyne formation. Selection of an appropriate oxidation/reduction sequence afforded access to either the cis- or trans-1-oxo-4-aryltetrahydrothi