4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Base Information

• Chemical Name: 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene
• CAS No.: 141667-46-1
• Molecular Formula: C₂₁H₂₀N₂O₅S₂
• Molecular Weight: 444.532
• Mol file: 141667-46-1.mol

Synonyms:4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Chemical Property of 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

There total 2 articles about 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1-nitroethylene (3638-64-0,26618-70-2) + 3-(4-methylbenzenesulfenyl)-1-(4'-methylbenzenesulfonyl)-2-pyridone (141667-32-5) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene (141667-46-1)

Guidance literature:

In dichloromethane; at 90 ℃; for 120h;

DOI:10.1021/jo00041a010

Reference yield:

3-(4-methylbenzenesulfenyl)-2-pyridone (107383-65-3) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene (141667-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) lithium hexamethyldisilazide / 1) THF, hexane, 0 deg C, 2) THF, hexane

2: 45 percent / CH₂Cl₂ / 120 h / 90 °C

With lithium hexamethyldisilazane; In dichloromethane;

DOI:10.1021/jo00041a010

Reference yield: 95.0%

4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-endo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene (141667-46-1) → 4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-exo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene (141725-50-0)

Guidance literature:

With ammonium formate; In methanol; dichloromethane; for 20h; Ambient temperature;

DOI:10.1021/jo00041a010

upstream raw materials:

1-nitroethylene

3-(4-methylbenzenesulfenyl)-1-(4'-methylbenzenesulfonyl)-2-pyridone

3-(4-methylbenzenesulfenyl)-2-pyridone

Downstream raw materials:

4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-5-exo-nitro-3-oxo-2-azabicyclo<2.2.2>oct-7-ene