9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

Base Information

Chemical Name:9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine
CAS No.:341536-45-6
Molecular Formula:C₄₁H₃₅N₅O₉
Molecular Weight:741.757
Hs Code.:

Synonyms:9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

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Chemical Property of 9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

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Technology Process of 9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

There total 1 articles about 9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 4005-49-6
N-benzoyladenine

: 230631-16-0
1,2-Di-O-acetyl-5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-L-threo-pentofuranose

: 341536-45-6
9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

Guidance literature:: With tin(IV) chloride; In dichloromethane;
DOI:10.1081/NCN-120022826

Reference yield: 85.0%

: 341536-45-6
9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

: 673456-34-3
C₃₉H₃₃N₅O₈

Guidance literature:: With ammonia; In methanol;
DOI:10.1081/NCN-120022826

Reference yield:

: 341536-45-6
9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

: 410076-88-9
(1S,3R,4S,7R)-1-(acetoxymethyl)-3-(6-N-benzoyladenin-9-yl)-7-benzyloxy-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 10 steps

1.1: NH₃ / methanol / 2 h / 0 °C

2.1: pyridine / toluene; CH₂Cl₂ / 2 h / -30 - 20 °C

3.1: 3.05 percent / 18-crown-6 / toluene / 0.5 h / 80 °C

4.1: NH₃ / methanol / 0.5 h / 20 °C

4.2: aq. NH₃ / methanol / 22 h / 20 °C

5.1: pyridine / 2.5 h / 20 °C

6.1: 16.5 h / 20 °C

7.1: 656 mg / aq. NH₃ / methanol / 6.5 h / 20 °C

8.1: 79 percent / pyridine / 2 h / 0 °C

9.1: NaH / tetrahydrofuran / 6.5 h / 0 °C

10.1: 911 mg / 18-crown-6 / dioxane / 19 h / Heating

With pyridine; ammonium hydroxide; 18-crown-6 ether; ammonia; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/ja0168763