methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

Base Information

Chemical Name:methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate
CAS No.:101212-47-9
Molecular Formula:C₄₉H₆₆O₆Si
Molecular Weight:779.145
Hs Code.:

methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

Synonyms:methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

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Chemical Property of methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

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Technology Process of methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

There total 29 articles about methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101212-46-8
2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester

: 101212-47-9
methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

Guidance literature:: With sodium dihydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol; at -20 ℃; for 5h; Yield given;

Reference yield:

: 82415-05-2
(2S,4S,6S,8R,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undecane-2-carbaldehyde

: 101212-47-9
methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

Guidance literature:: Multi-step reaction with 17 steps

1: tetrahydrofuran / 2 h / -80 °C

2: 80 percent / pyridine / 0 °C

3: 88 percent / imidazole / dimethylformamide / Ambient temperature

4: 80 percent / dimethylformamide / 12 h / 70 °C

5: di-isobutylaluminium hydride / CH₂Cl₂ / 5 h / Ambient temperature; 1.) -78 deg C --> room temp., 1 h

6: CH₂Cl₂ / 0 deg C, then room temp. overnight

7: 60 percent / di-isobutylaluminium hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / -78 deg C --> room temp., overnight

8: triethylamine, dimethylaminopyridine / CH₂Cl₂ / 0 °C

9: sodium iodide / tetrahydrofuran / 12 h

10: 80 percent / tetrahydrofuran / -20 °C

11: lithium aluminium hydride / diethyl ether / 1 h / 0 °C

12: pyridine / 0 °C

13: 90 percent / sodium / methanol / Ambient temperature

14: 90 percent / KHSO₅ / H₂O; ethanol / 5 h / 0 °C

15: 1.) t-butyl-lithium / 1.) hexane, THF, -80 deg C; -50 deg C, 1 h; 2.) THF, -50 deg C, 1 h

16: tetrahydrofuran / 0.17 h / -50 °C / 2.) room temp., 2 h

17: sodium amalgam, sodium dihydrogen orthophosphate / methanol; tetrahydrofuran / 5 h / -20 °C

With 1H-imidazole; dmap; sodium dihydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; potassium peroxomonosulfate; diisobutylaluminum hydride; tert.-butyl lithium; sodium; triethylamine; sodium iodide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 82415-18-7
(2S,4S,6S,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane-2-methanol

: 101212-47-9
methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate

Guidance literature:: Multi-step reaction with 18 steps

1: 1.) dimethylsulphoxide, oxalyl chloride; 2.) triethylamine / 1.) THF, -80 deg C --> -40 deg C, 5 min; 2.) 0 deg C, 5 min

2: tetrahydrofuran / 2 h / -80 °C

3: 80 percent / pyridine / 0 °C

4: 88 percent / imidazole / dimethylformamide / Ambient temperature

5: 80 percent / dimethylformamide / 12 h / 70 °C

6: di-isobutylaluminium hydride / CH₂Cl₂ / 5 h / Ambient temperature; 1.) -78 deg C --> room temp., 1 h

7: CH₂Cl₂ / 0 deg C, then room temp. overnight

8: 60 percent / di-isobutylaluminium hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / -78 deg C --> room temp., overnight

9: triethylamine, dimethylaminopyridine / CH₂Cl₂ / 0 °C

10: sodium iodide / tetrahydrofuran / 12 h

11: 80 percent / tetrahydrofuran / -20 °C

12: lithium aluminium hydride / diethyl ether / 1 h / 0 °C

13: pyridine / 0 °C

14: 90 percent / sodium / methanol / Ambient temperature

15: 90 percent / KHSO₅ / H₂O; ethanol / 5 h / 0 °C

16: 1.) t-butyl-lithium / 1.) hexane, THF, -80 deg C; -50 deg C, 1 h; 2.) THF, -50 deg C, 1 h

17: tetrahydrofuran / 0.17 h / -50 °C / 2.) room temp., 2 h

18: sodium amalgam, sodium dihydrogen orthophosphate / methanol; tetrahydrofuran / 5 h / -20 °C

With 1H-imidazole; dmap; sodium dihydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; potassium peroxomonosulfate; oxalyl dichloride; diisobutylaluminum hydride; tert.-butyl lithium; sodium; dimethyl sulfoxide; triethylamine; sodium iodide; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;