5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester

Base Information

• Chemical Name: 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester
• CAS No.: 227275-24-3
• Molecular Formula: C₁₅H₁₄N₂O₅
• Molecular Weight: 302.287
• Mol file: 227275-24-3.mol

Synonyms:5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester

Chemical Property of 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester

There total 3 articles about 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-(4-methoxycarbonyl-2-nitrophenoxy)nicotinate (227275-04-9) → 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester (227275-24-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; at 20 ℃; under 2280 Torr;

DOI:10.1016/S0968-0896(01)00023-2

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester (227275-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.1 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / Pd/C / methanol; dioxane / 20 °C / 2280 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00023-2

Reference yield:

methyl 5-hydroxy-3-pyridinecarboxylate (30766-22-4) → 5-(2-amino-4-methoxycarbonyl-phenoxy)-nicotinic acid methyl ester (227275-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68.1 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: H₂ / Pd/C / methanol; dioxane / 20 °C / 2280 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00023-2

upstream raw materials:

methyl 5-(4-methoxycarbonyl-2-nitrophenoxy)nicotinate

4-fluoro-3-nitro-benzoic acid methyl ester

methyl 5-hydroxy-3-pyridinecarboxylate

Downstream raw materials:

methyl 5-[4-methoxycarbonyl-2-(4-octadecanoylaminobenzoylamino)phenoxy]nicotinate

methyl 5-[4-methoxycarbonyl-2-(4-aminobenzoylamino)phenoxy]nicotinate

methyl 5-[4-methoxycarbonyl-2-(4-nitrobenzoylamino)phenoxy]nicotinate